منابع مشابه
Simian adenoviruses as vaccine vectors
Replication incompetent human adenovirus serotype 5 (HAdV-C5) has been extensively used as a delivery vehicle for gene therapy proteins and infectious disease antigens. These vectors infect replicating and nonreplicating cells, have a broad tissue tropism, elicit high immune responses and are easily purified to high titers. However, the utility of HAdV-C5 vectors as potential vaccines is limite...
متن کاملAmplicons as vaccine vectors.
HSV-1 amplicon vectors efficiently transduce cultured antigen-presenting cells (APC), including both human and murine dendritic cells as well as primary human chronic lymphocytic leukemia (CLL) B cells. Helper-free amplicons have been shown to be especially well-suited for this purpose, since they do not impair the antigen-presenting functions of these target cells. In vivo, amplicon vectors ha...
متن کاملAttenuated vesicular stomatitis viruses as vaccine vectors.
We showed previously that a single intranasal vaccination of mice with a recombinant vesicular stomatitis virus (VSV) expressing an influenza virus hemagglutinin (HA) protein provided complete protection from lethal challenge with influenza virus (A. Roberts, E. Kretzschmar, A. S. Perkins, J. Forman, R. Price, L. Buonocore, Y. Kawaoka, and J. K. Rose, J. Virol. 72:4704-4711, 1998). Because some...
متن کاملRecombinant adenoviruses as expression vectors and as probes for DNA repair in human cells
_________________________________________________________________________________________________ *Correspondence: Dr. Andrew J. Rainbow, Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Tel: (905) 5259140 Ext. 23544 Fax: (905)-522-6066; E-mail: [email protected]
متن کاملPathogenic Bacteria as Vaccine Vectors: Teaching Old Bugs New Tricks
As our scientific knowledge of bacteria grows, so does our ability to manipulate these bacteria to protect rather than infect mammalian hosts from a diverse group of diseases. The old axiom that the best way to protect from a disease is to get infected in the first place is not feasible in the face of the diverse group of pathogens that infect humans. Therefore, reprogramming bacteria to protec...
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2004
ISSN: 1525-0016
DOI: 10.1016/j.ymthe.2004.07.013